Revitalization of a diastemal tooth primordium in Spry2 null mice results from increased proliferation and decreased apoptosis
Identifieur interne : 000153 ( France/Analysis ); précédent : 000152; suivant : 000154Revitalization of a diastemal tooth primordium in Spry2 null mice results from increased proliferation and decreased apoptosis
Auteurs : Renata Peterkova [République tchèque, États-Unis] ; Svatava Churava [République tchèque] ; Herve Lesot [France, Royaume-Uni] ; Michaela Rothova [République tchèque] ; Jan Prochazka [République tchèque] ; Miroslav Peterka [République tchèque] ; Ophir D. Klein [États-Unis]Source :
- Journal of Experimental Zoology Part B: Molecular and Developmental Evolution [ 1552-5007 ] ; 2009-06-15.
English descriptors
- KwdEn :
- Anterior, Anterior elevation, Anterior part, Apoptosis, Apoptotic, Apoptotic bodies, Apoptotic cells, Apoptotic elements, Biol, Biol peterkova, Cell death, Cheek region, Czech, Czech republic, Dental epithelium, Dentition, Diastema, Diastemal, Diastemal buds, Diastemal tooth primordium, Embryo, Embryonic, Enamel, Enamel knot, Enamel organ, Epithelial, Epithelium, Evol, Fgf4, Frontal sections, Growth activators, Growth inhibitors, Histological, Histological sections, Incisor, Jernvall, Klein, Large diastemal buds, Lef1, Leica, Leica microsystems gmbh, Lesot, Lower molar, Mandible, Mesenchyme, Mitotic, Mitotic index, Molar, Molar epithelium, Molar region, More posteriorly, Morphogenesis, Mouse, Mutant, Mutant mice, Pathway, Peterka, Peterkova, Posterior diastemal, Posterior part, Premolar, Primordium, Quantitative evaluation, Regeneration, Revitalization, Ruch, Rudiment, Rudimentary diastemal, Rudiments, Sprouty, Spry2, Supernumerary, Supernumerary teeth, Supernumerary tooth, Supernumerary tooth primordium, Tabby, Thesleff, Tooth, Tooth development, Tooth primordia, Tooth regeneration, Tureckova, Viriot, Vonesch, Zool.
- Teeft :
- Anterior, Anterior elevation, Anterior part, Apoptosis, Apoptotic, Apoptotic bodies, Apoptotic cells, Apoptotic elements, Biol, Biol peterkova, Cell death, Cheek region, Czech, Czech republic, Dental epithelium, Dentition, Diastema, Diastemal, Diastemal buds, Diastemal tooth primordium, Embryo, Embryonic, Enamel, Enamel knot, Enamel organ, Epithelial, Epithelium, Evol, Fgf4, Frontal sections, Growth activators, Growth inhibitors, Histological, Histological sections, Incisor, Jernvall, Klein, Large diastemal buds, Lef1, Leica, Leica microsystems gmbh, Lesot, Lower molar, Mandible, Mesenchyme, Mitotic, Mitotic index, Molar, Molar epithelium, Molar region, More posteriorly, Morphogenesis, Mouse, Mutant, Mutant mice, Pathway, Peterka, Peterkova, Posterior diastemal, Posterior part, Premolar, Primordium, Quantitative evaluation, Regeneration, Revitalization, Ruch, Rudiment, Rudimentary diastemal, Rudiments, Sprouty, Spry2, Supernumerary, Supernumerary teeth, Supernumerary tooth, Supernumerary tooth primordium, Tabby, Thesleff, Tooth, Tooth development, Tooth primordia, Tooth regeneration, Tureckova, Viriot, Vonesch, Zool.
Abstract
An understanding of the factors that promote or inhibit tooth development is essential for designing biological tooth replacements. The embryonic mouse dentition provides an ideal system for studying such factors because it consists of two types of tooth primordia. One type of primordium will go on to form a functional tooth, whereas the other initiates development but arrests at or before the bud stage. This developmental arrest contributes to the formation of the toothless mouse diastema. It is accompanied by the apoptosis of the rudimentary diastemal buds, which presumably results from the insufficient activity of anti‐apoptotic signals such as fibroblast growth factors (FGFs). We have previously shown that the arrest of a rudimentary tooth bud can be rescued by inactivating Spry2, an antagonist of FGF signaling. Here, we studied the role of the epithelial cell death and proliferation in this process by comparing the development of a rudimentary diastemal tooth bud (R2) and the first molar in the mandibles of Spry2−/− and wild‐type (WT) embryos using histological sections, image analysis and 3D reconstructions. In the WT R2 at embryonic day 13.5, significantly increased apoptosis and decreased proliferation were found compared with the first molar. In contrast, increased levels of FGF signaling in Spry2−/− embryos led to significantly decreased apoptosis and increased proliferation in the R2 bud. Consequently, the R2 was involved in the formation of a supernumerary tooth primordium. Studies of the revitalization of rudimentary tooth primordia in mutant mice can help to lay the foundation for tooth regeneration by enhancing our knowledge of mechanisms that regulate tooth formation. J. Exp. Zool. (Mol. Dev. Evol.) 312B:292–308, 2009. © 2009 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/jez.b.21266
Affiliations:
- France, Royaume-Uni, République tchèque, États-Unis
- Alsace (région administrative), Bohême centrale, Californie, Grand Est
- Prague, Strasbourg
- Université Strasbourg 1
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Links to Exploration step
ISTEX:ECB51DFAF6AA56FBA9FD37985D1C2498853C8161Le document en format XML
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Klein, Departments of Orofacial Sciences and Pediatrics, University of California, San Francisco</wicri:cityArea></affiliation></author><author><name sortKey="Churava, Svatava" sort="Churava, Svatava" uniqKey="Churava S" first="Svatava" last="Churava">Svatava Churava</name><affiliation wicri:level="3"><country xml:lang="fr">République tchèque</country><wicri:regionArea>Department of Teratology, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague</wicri:regionArea><placeName><settlement type="city">Prague</settlement><region type="région" nuts="2">Bohême centrale</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">République tchèque</country><wicri:regionArea>Department of Anthropology, Faculty of Science, Charles University, Prague</wicri:regionArea><placeName><settlement type="city">Prague</settlement><region type="région" nuts="2">Bohême centrale</region></placeName></affiliation></author><author><name sortKey="Lesot, Herve" sort="Lesot, Herve" uniqKey="Lesot H" first="Herve" last="Lesot">Herve Lesot</name><affiliation wicri:level="4"><country xml:lang="fr">France</country><wicri:regionArea>INSERM U595, Faculté de Médecine, Université Louis Pasteur, Strasbourg</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Alsace (région administrative)</region><settlement type="city">Strasbourg</settlement><settlement type="city">Strasbourg</settlement></placeName><orgName type="university">Université Strasbourg 1</orgName></affiliation><affiliation wicri:level="4"><country xml:lang="fr">France</country><wicri:regionArea>Faculté de Chirurgie Dentaire, Université Louis Pasteur, Strasbourg</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Alsace (région administrative)</region><settlement type="city">Strasbourg</settlement><settlement type="city">Strasbourg</settlement></placeName><orgName type="university">Université Strasbourg 1</orgName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>International Collaborating Centre in Oro‐Facial Genetics and Development, University of Liverpool, Liverpool</wicri:regionArea><wicri:noRegion>Liverpool</wicri:noRegion></affiliation></author><author><name sortKey="Rothova, Michaela" sort="Rothova, Michaela" uniqKey="Rothova M" first="Michaela" last="Rothova">Michaela Rothova</name><affiliation wicri:level="3"><country xml:lang="fr">République tchèque</country><wicri:regionArea>Department of Teratology, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague</wicri:regionArea><placeName><settlement type="city">Prague</settlement><region type="région" nuts="2">Bohême centrale</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">République tchèque</country><wicri:regionArea>Department of Developmental Biology, Faculty of Science, Charles University, Prague</wicri:regionArea><placeName><settlement type="city">Prague</settlement><region type="région" nuts="2">Bohême centrale</region></placeName></affiliation></author><author><name sortKey="Prochazka, Jan" sort="Prochazka, Jan" uniqKey="Prochazka J" first="Jan" last="Prochazka">Jan Prochazka</name><affiliation wicri:level="3"><country xml:lang="fr">République tchèque</country><wicri:regionArea>Department of Teratology, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague</wicri:regionArea><placeName><settlement type="city">Prague</settlement><region type="région" nuts="2">Bohême centrale</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">République tchèque</country><wicri:regionArea>Department of Developmental Biology, Faculty of Science, Charles University, Prague</wicri:regionArea><placeName><settlement type="city">Prague</settlement><region type="région" nuts="2">Bohême centrale</region></placeName></affiliation></author><author><name sortKey="Peterka, Miroslav" sort="Peterka, Miroslav" uniqKey="Peterka M" first="Miroslav" last="Peterka">Miroslav Peterka</name><affiliation wicri:level="3"><country xml:lang="fr">République tchèque</country><wicri:regionArea>Department of Teratology, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague</wicri:regionArea><placeName><settlement type="city">Prague</settlement><region type="région" nuts="2">Bohême centrale</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">République tchèque</country><wicri:regionArea>Department of Anthropology, Faculty of Science, Charles University, Prague</wicri:regionArea><placeName><settlement type="city">Prague</settlement><region type="région" nuts="2">Bohême centrale</region></placeName></affiliation></author><author><name sortKey="Klein, Ophir D" sort="Klein, Ophir D" uniqKey="Klein O" first="Ophir D." last="Klein">Ophir D. Klein</name><affiliation wicri:level="2"><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Orofacial Sciences, University of California, San Francisco</wicri:cityArea></affiliation><affiliation wicri:level="2"><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Pediatrics, University of California, San Francisco</wicri:cityArea></affiliation><affiliation wicri:level="2"><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Institutes of Human Genetics and Regeneration Medicine, University of California, San Francisco</wicri:cityArea></affiliation><affiliation wicri:level="1"><country wicri:rule="url">États-Unis</country></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Renata Peterkova, Department of Teratology, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, v.v.i., Videnska 1083, 14220 Prague, Czech Republic===Ophir D. Klein, Departments of Orofacial Sciences and Pediatrics, University of California, San Francisco</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Experimental Zoology Part B: Molecular and Developmental Evolution</title><title level="j" type="sub">Tooth Development in Evolution and Disease, Part 1</title><title level="j" type="alt">JOURNAL OF EXPERIMENTAL ZOOLOGY PART B: MOLECULAR AND DEVELOPMENTAL EVOLUTION</title><idno type="ISSN">1552-5007</idno><idno type="eISSN">1552-5015</idno><imprint><biblScope unit="vol">312B</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="292">292</biblScope><biblScope unit="page" to="308">308</biblScope><biblScope unit="page-count">17</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-06-15">2009-06-15</date></imprint><idno type="ISSN">1552-5007</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1552-5007</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anterior</term><term>Anterior elevation</term><term>Anterior part</term><term>Apoptosis</term><term>Apoptotic</term><term>Apoptotic bodies</term><term>Apoptotic cells</term><term>Apoptotic elements</term><term>Biol</term><term>Biol peterkova</term><term>Cell death</term><term>Cheek region</term><term>Czech</term><term>Czech republic</term><term>Dental epithelium</term><term>Dentition</term><term>Diastema</term><term>Diastemal</term><term>Diastemal buds</term><term>Diastemal tooth primordium</term><term>Embryo</term><term>Embryonic</term><term>Enamel</term><term>Enamel knot</term><term>Enamel organ</term><term>Epithelial</term><term>Epithelium</term><term>Evol</term><term>Fgf4</term><term>Frontal sections</term><term>Growth activators</term><term>Growth inhibitors</term><term>Histological</term><term>Histological sections</term><term>Incisor</term><term>Jernvall</term><term>Klein</term><term>Large diastemal buds</term><term>Lef1</term><term>Leica</term><term>Leica microsystems gmbh</term><term>Lesot</term><term>Lower molar</term><term>Mandible</term><term>Mesenchyme</term><term>Mitotic</term><term>Mitotic index</term><term>Molar</term><term>Molar epithelium</term><term>Molar region</term><term>More posteriorly</term><term>Morphogenesis</term><term>Mouse</term><term>Mutant</term><term>Mutant mice</term><term>Pathway</term><term>Peterka</term><term>Peterkova</term><term>Posterior diastemal</term><term>Posterior part</term><term>Premolar</term><term>Primordium</term><term>Quantitative evaluation</term><term>Regeneration</term><term>Revitalization</term><term>Ruch</term><term>Rudiment</term><term>Rudimentary diastemal</term><term>Rudiments</term><term>Sprouty</term><term>Spry2</term><term>Supernumerary</term><term>Supernumerary teeth</term><term>Supernumerary tooth</term><term>Supernumerary tooth primordium</term><term>Tabby</term><term>Thesleff</term><term>Tooth</term><term>Tooth development</term><term>Tooth primordia</term><term>Tooth regeneration</term><term>Tureckova</term><term>Viriot</term><term>Vonesch</term><term>Zool</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Anterior</term><term>Anterior elevation</term><term>Anterior part</term><term>Apoptosis</term><term>Apoptotic</term><term>Apoptotic bodies</term><term>Apoptotic cells</term><term>Apoptotic elements</term><term>Biol</term><term>Biol peterkova</term><term>Cell death</term><term>Cheek region</term><term>Czech</term><term>Czech republic</term><term>Dental epithelium</term><term>Dentition</term><term>Diastema</term><term>Diastemal</term><term>Diastemal buds</term><term>Diastemal tooth primordium</term><term>Embryo</term><term>Embryonic</term><term>Enamel</term><term>Enamel knot</term><term>Enamel organ</term><term>Epithelial</term><term>Epithelium</term><term>Evol</term><term>Fgf4</term><term>Frontal sections</term><term>Growth activators</term><term>Growth inhibitors</term><term>Histological</term><term>Histological sections</term><term>Incisor</term><term>Jernvall</term><term>Klein</term><term>Large diastemal buds</term><term>Lef1</term><term>Leica</term><term>Leica microsystems gmbh</term><term>Lesot</term><term>Lower molar</term><term>Mandible</term><term>Mesenchyme</term><term>Mitotic</term><term>Mitotic index</term><term>Molar</term><term>Molar epithelium</term><term>Molar region</term><term>More posteriorly</term><term>Morphogenesis</term><term>Mouse</term><term>Mutant</term><term>Mutant mice</term><term>Pathway</term><term>Peterka</term><term>Peterkova</term><term>Posterior diastemal</term><term>Posterior part</term><term>Premolar</term><term>Primordium</term><term>Quantitative evaluation</term><term>Regeneration</term><term>Revitalization</term><term>Ruch</term><term>Rudiment</term><term>Rudimentary diastemal</term><term>Rudiments</term><term>Sprouty</term><term>Spry2</term><term>Supernumerary</term><term>Supernumerary teeth</term><term>Supernumerary tooth</term><term>Supernumerary tooth primordium</term><term>Tabby</term><term>Thesleff</term><term>Tooth</term><term>Tooth development</term><term>Tooth primordia</term><term>Tooth regeneration</term><term>Tureckova</term><term>Viriot</term><term>Vonesch</term><term>Zool</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">An understanding of the factors that promote or inhibit tooth development is essential for designing biological tooth replacements. The embryonic mouse dentition provides an ideal system for studying such factors because it consists of two types of tooth primordia. One type of primordium will go on to form a functional tooth, whereas the other initiates development but arrests at or before the bud stage. This developmental arrest contributes to the formation of the toothless mouse diastema. It is accompanied by the apoptosis of the rudimentary diastemal buds, which presumably results from the insufficient activity of anti‐apoptotic signals such as fibroblast growth factors (FGFs). We have previously shown that the arrest of a rudimentary tooth bud can be rescued by inactivating Spry2, an antagonist of FGF signaling. Here, we studied the role of the epithelial cell death and proliferation in this process by comparing the development of a rudimentary diastemal tooth bud (R2) and the first molar in the mandibles of Spry2−/− and wild‐type (WT) embryos using histological sections, image analysis and 3D reconstructions. In the WT R2 at embryonic day 13.5, significantly increased apoptosis and decreased proliferation were found compared with the first molar. In contrast, increased levels of FGF signaling in Spry2−/− embryos led to significantly decreased apoptosis and increased proliferation in the R2 bud. Consequently, the R2 was involved in the formation of a supernumerary tooth primordium. Studies of the revitalization of rudimentary tooth primordia in mutant mice can help to lay the foundation for tooth regeneration by enhancing our knowledge of mechanisms that regulate tooth formation. J. Exp. Zool. (Mol. Dev. Evol.) 312B:292–308, 2009. © 2009 Wiley‐Liss, Inc.</div></front></TEI><affiliations><list><country><li>France</li><li>Royaume-Uni</li><li>République tchèque</li><li>États-Unis</li></country><region><li>Alsace (région administrative)</li><li>Bohême centrale</li><li>Californie</li><li>Grand Est</li></region><settlement><li>Prague</li><li>Strasbourg</li></settlement><orgName><li>Université Strasbourg 1</li></orgName></list><tree><country name="République tchèque"><region name="Bohême centrale"><name sortKey="Peterkova, Renata" sort="Peterkova, Renata" uniqKey="Peterkova R" first="Renata" last="Peterkova">Renata Peterkova</name></region><name sortKey="Churava, Svatava" sort="Churava, Svatava" uniqKey="Churava S" first="Svatava" last="Churava">Svatava Churava</name><name sortKey="Churava, Svatava" sort="Churava, Svatava" uniqKey="Churava S" first="Svatava" last="Churava">Svatava Churava</name><name sortKey="Peterka, Miroslav" sort="Peterka, Miroslav" uniqKey="Peterka M" first="Miroslav" last="Peterka">Miroslav Peterka</name><name sortKey="Peterka, Miroslav" sort="Peterka, Miroslav" uniqKey="Peterka M" first="Miroslav" last="Peterka">Miroslav Peterka</name><name sortKey="Peterkova, Renata" sort="Peterkova, Renata" uniqKey="Peterkova R" first="Renata" last="Peterkova">Renata Peterkova</name><name sortKey="Prochazka, Jan" sort="Prochazka, Jan" uniqKey="Prochazka J" first="Jan" last="Prochazka">Jan Prochazka</name><name sortKey="Prochazka, Jan" sort="Prochazka, Jan" uniqKey="Prochazka J" first="Jan" last="Prochazka">Jan Prochazka</name><name sortKey="Rothova, Michaela" sort="Rothova, Michaela" uniqKey="Rothova M" first="Michaela" last="Rothova">Michaela Rothova</name><name sortKey="Rothova, Michaela" sort="Rothova, Michaela" uniqKey="Rothova M" first="Michaela" last="Rothova">Michaela Rothova</name></country><country name="États-Unis"><region name="Californie"><name sortKey="Peterkova, Renata" sort="Peterkova, Renata" uniqKey="Peterkova R" first="Renata" last="Peterkova">Renata Peterkova</name></region><name sortKey="Klein, Ophir D" sort="Klein, Ophir D" uniqKey="Klein O" first="Ophir D." last="Klein">Ophir D. Klein</name><name sortKey="Klein, Ophir D" sort="Klein, Ophir D" uniqKey="Klein O" first="Ophir D." last="Klein">Ophir D. Klein</name><name sortKey="Klein, Ophir D" sort="Klein, Ophir D" uniqKey="Klein O" first="Ophir D." last="Klein">Ophir D. Klein</name><name sortKey="Klein, Ophir D" sort="Klein, Ophir D" uniqKey="Klein O" first="Ophir D." last="Klein">Ophir D. Klein</name><name sortKey="Klein, Ophir D" sort="Klein, Ophir D" uniqKey="Klein O" first="Ophir D." last="Klein">Ophir D. Klein</name></country><country name="France"><region name="Grand Est"><name sortKey="Lesot, Herve" sort="Lesot, Herve" uniqKey="Lesot H" first="Herve" last="Lesot">Herve Lesot</name></region><name sortKey="Lesot, Herve" sort="Lesot, Herve" uniqKey="Lesot H" first="Herve" last="Lesot">Herve Lesot</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Lesot, Herve" sort="Lesot, Herve" uniqKey="Lesot H" first="Herve" last="Lesot">Herve Lesot</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= Revitalization of a diastemal tooth primordium in Spry2 null mice results from increased proliferation and decreased apoptosis
}}
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